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Bulmer, Gregory S., de Andrade, Peterson, Field, Robert A. 
ORCID: https://orcid.org/0000-0001-8574-0275 and van Munster, Jolanda M.
(2021)
Recent advances in enzymatic synthesis of β-glucan and cellulose.
Carbohydrate Research, 508.
ISSN 0008-6215
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Abstract
Bottom-up synthesis of β-glucans such as callose, fungal β-(1,3)(1,6)-glucan and cellulose, can create the defined compounds that are needed to perform fundamental studies on glucan properties and develop applications. With the importance of β-glucans and cellulose in high-profile fields such as nutrition, renewables-based biotechnology and materials science, the enzymatic synthesis of such relevant carbohydrates and their derivatives has attracted much attention. Here we review recent developments in enzymatic synthesis of β-glucans and cellulose, with a focus on progress made over the last five years. We cover the different types of biocatalysts employed, their incorporation in cascades, the exploitation of enzyme promiscuity and their engineering, and reaction conditions affecting the production as well as in situ self-assembly of (non)functionalised glucans. The recent achievements in the application of glycosyl transferases and β-1,4- and β-1,3-glucan phosphorylases demonstrate the high potential and versatility of these biocatalysts in glucan synthesis in both industrial and academic contexts.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: This work was supported by the UK BBSRC via a personal fellowship (BB/P011462/1), and the EPSRC via the GelEnz consortium (IUK 59000 442149) and DTP EP/N509565/1. |
| Uncontrolled Keywords: | cellulose,glucans,glycoside hydrolases,glycoside phosphorylases,glycosyltransferases,nanostructures,analytical chemistry,biochemistry,organic chemistry,sdg 7 - affordable and clean energy ,/dk/atira/pure/subjectarea/asjc/1600/1602 |
| Faculty \ School: | Faculty of Science > School of Chemistry, Pharmacy and Pharmacology |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 02 Sep 2024 15:30 |
| Last Modified: | 02 Oct 2024 23:59 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/96433 |
| DOI: | 10.1016/j.carres.2021.108411 |
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