The inositol phosphate signalling network in physiology and disease

Kim, Seyun, Bhandari, Rashna, Brearley, Charles A. ORCID: https://orcid.org/0000-0001-6179-9109 and Saiardi, Adolfo (2024) The inositol phosphate signalling network in physiology and disease. Trends in Biochemical Sciences. ISSN 0968-0004

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Abstract

Combinatorial substitution of phosphate groups on the inositol ring gives rise to a plethora of inositol phosphates (InsPs) and inositol pyrophosphates (PP-InsPs). These small molecules constitute an elaborate metabolic and signalling network that influences nearly every cellular function. This review delves into the knowledge accumulated over the past decades regarding the biochemical principles and significance of InsP metabolism. We focus on the biological actions of InsPs in mammals, with an emphasis on recent findings regarding specific target proteins. We further discuss the roles of InsP metabolism in contributing to physiological homeostasis and pathological conditions. A deeper understanding of InsPs and their metabolic pathways holds the potential to address unresolved questions and propel advances towards therapeutic applications.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Biological Sciences
UEA Research Groups:	Faculty of Science > Research Groups > Plant Sciences Faculty of Science > Research Groups > Molecular Microbiology
Depositing User:	LivePure Connector
Date Deposited:	29 Aug 2024 14:30
Last Modified:	29 Sep 2024 06:31
URI:	https://ueaeprints.uea.ac.uk/id/eprint/96398
DOI:	10.1016/j.tibs.2024.08.005

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