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Kim, Seyun, Bhandari, Rashna, Brearley, Charles A. 
ORCID: https://orcid.org/0000-0001-6179-9109 and Saiardi, Adolfo
(2024)
The inositol phosphate signalling network in physiology and disease.
Trends in Biochemical Sciences, 49 (11).
pp. 969-985.
ISSN 0968-0004
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Abstract
Combinatorial substitution of phosphate groups on the inositol ring gives rise to a plethora of inositol phosphates (InsPs) and inositol pyrophosphates (PP-InsPs). These small molecules constitute an elaborate metabolic and signalling network that influences nearly every cellular function. This review delves into the knowledge accumulated over the past decades regarding the biochemical principles and significance of InsP metabolism. We focus on the biological actions of InsPs in mammals, with an emphasis on recent findings regarding specific target proteins. We further discuss the roles of InsP metabolism in contributing to physiological homeostasis and pathological conditions. A deeper understanding of InsPs and their metabolic pathways holds the potential to address unresolved questions and propel advances towards therapeutic applications.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: S.K. is supported by the National Research Foundation of Korea (NRF-2018R1A5A1024261 and RS-2023-00278918). R.B. acknowledges support from the Department of Biotechnology , Ministry of Science and Technology , Government of India (IC-12025(11)/2/2020/ICD-DBT). C.A.B. is supported by the Natural Environment Research Council grant NE/W000350/1. A.S. is supported by the Medical Research Council grant MR/T028904/1. |
| Uncontrolled Keywords: | kinase,metabolism,phosphatase,physiology,signal transduction,biochemistry,molecular biology ,/dk/atira/pure/subjectarea/asjc/1300/1303 |
| Faculty \ School: | Faculty of Science > School of Biological Sciences |
| UEA Research Groups: | Faculty of Science > Research Groups > Plant Sciences Faculty of Science > Research Groups > Molecular Microbiology |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 29 Aug 2024 14:30 |
| Last Modified: | 08 Nov 2024 09:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/96398 |
| DOI: | 10.1016/j.tibs.2024.08.005 |
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