Extensive immune receptor repertoire diversity in disease-resistant rice landraces

Gladieux, Pierre, van Oosterhout, Cock ORCID: https://orcid.org/0000-0002-5653-738X, Fairhead, Sebastian, Jouet, Agathe, Ortiz, Diana, Ravel, Sebastien, Shrestha, Ram-Krishna, Frouin, Julien, He, Xiahong, Zhu, Youyong, Morel, Jean-Benoit, Huang, Huichuan, Kroj, Thomas and Jones, Jonathan D. G. (2024) Extensive immune receptor repertoire diversity in disease-resistant rice landraces. Current Biology, 34 (17). 3983-3995.e6. ISSN 0960-9822

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Abstract

Plants have powerful defense mechanisms and extensive immune receptor repertoires, yet crop monocultures are prone to epidemic diseases. Rice (Oryza sativa) is susceptible to many diseases, such as rice blast caused by Magnaporthe oryzae. Varietal resistance of rice to blast relies on intracellular nucleotide binding, leucine-rich repeat (NLR) receptors that recognize specific pathogen molecules and trigger immune responses. In the Yuanyang terraces in southwest China, rice landraces rarely show severe losses to disease whereas commercial inbred lines show pronounced field susceptibility. Here, we investigate within-landrace NLR sequence diversity of nine rice landraces and eleven modern varieties using complexity reduction techniques. We find that NLRs display high sequence diversity in landraces, consistent with balancing selection, and that balancing selection at NLRs is more pervasive in landraces than modern varieties. Notably, modern varieties lack many ancient NLR haplotypes that are retained in some landraces. Our study emphasizes the value of standing genetic variation that is maintained in farmer landraces as a resource to make modern crops and agroecosystems less prone to disease. The conservation of landraces is, therefore, crucial for ensuring food security in the face of dynamic biotic and abiotic threats.

Item Type:	Article
Additional Information:	Funding information: This work was supported by a grant from the Gordon and Betty Moore Foundation to the 2Blades Foundation (GBMF4725) (J.D.G.J., A.J., and S.F.), by the Gatsby Charitable Foundation (A.J., S.F., and J.D.G.J.), by BBSRC grant BB/P021646/1 (S.F. and J.D.G.J.), by the Earth and Life Systems Alliance (ELSA) (A.J. and C.v.O.), and by Yunnan Fundamental Research Projects (202301AS070257) (H.H.).
Faculty \ School:	Faculty of Science > School of Environmental Sciences Faculty of Science > The Sainsbury Laboratory Faculty of Science > School of Biological Sciences
UEA Research Groups:	Faculty of Science > Research Centres > Centre for Ecology, Evolution and Conservation Faculty of Science > Research Groups > Plant Sciences
Depositing User:	LivePure Connector
Date Deposited:	29 Aug 2024 11:30
Last Modified:	25 Sep 2024 18:04
URI:	https://ueaeprints.uea.ac.uk/id/eprint/96391
DOI:	10.1016/j.cub.2024.07.061

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