Parent-mediated intervention in infants with an elevated likelihood for autism reduces dwell time during a gaze following task

Bedford, Rachael, Green, Jonathan, Gliga, Teodora, Jones, Emily H., Elsabbagh, Mayada, Pasco, Greg, Wan, Ming Wai, Slonims, Vicky, Charman, Tony, Pickles, Andrew and Johnson, Mark H. and The BASIS Team (2024) Parent-mediated intervention in infants with an elevated likelihood for autism reduces dwell time during a gaze following task. Autism Research, 17 (11). pp. 2346-2354. ISSN 1939-3792

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Abstract

Cognitive markers may in theory be more sensitive to the effects of intervention than overt behavioral measures. The current study tests the impact of the Intervention with the British Autism Study of Infant Siblings—Video Interaction for Promoting Positive Parenting (iBASIS-VIPP) on an eye-tracking measure of social attention: dwell time to the referred object in a gaze following task. The original two-site, two-arm, assessor-blinded randomized controlled trial (RCT) of this intervention to increase parental awareness, and responsiveness to their infant, was run with infants who have an elevated familial likelihood for autism (EL). Fifty-four EL infants (28 iBASIS-VIPP intervention, 26 no intervention) were enrolled, and the intervention took place between 9 months (baseline) and 15 months (endpoint), with gaze following behavior measured at 15 months. Secondary intention to treat (ITT) analysis showed that the intervention was associated with significantly reduced dwell time to the referent of another person's gaze (β = −0.32, SE = 0.14, p = 0.03) at 15-month treatment endpoint. Given the established link between gaze following and language, the results are considered in the context of a previously reported, non-significant and transient trend toward lower language scores at the treatment endpoint (Green et al. (2015) The Lancet Psychiatry, 2(2), 133–140). Future intervention trials should aim to include experimental cognitive measures, alongside behavioral measures, to investigate mechanisms associated with intervention effects.

Item Type:	Article
Additional Information:	Research funding: Autistica. Grant Number: 7267; The Waterloo Foundation; Autism Speaks; UK Medical Research Council. Grant Number: MR/T003057/1; NIHR Biomedical Research Centre for Mental Health at the South London Maudsley NHS Foundation Trust; National Institute for Health Research. Grant Numbers: NF-SI-0617-10168, NF-SI-0617-10120.
Uncontrolled Keywords:	rct,autism,elevated likelihood for autism,gaze following,infant siblings,intervention,parent-mediated intervention,neuroscience(all),clinical neurology,genetics(clinical),3*,unique data; complex stats ,/dk/atira/pure/subjectarea/asjc/2800
Faculty \ School:	Faculty of Social Sciences > School of Psychology
UEA Research Groups:	Faculty of Social Sciences > Research Groups > Developmental Science
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	28 Aug 2024 10:30
Last Modified:	18 Nov 2024 12:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/96366
DOI:	10.1002/aur.3223

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