Menopause and Alzheimer’s disease susceptibility: Exploring the potential mechanisms

Breeze, Bernadette ORCID: https://orcid.org/0000-0002-2563-8823, Connell, Emily, Wileman, Tom, Muller, Michael ORCID: https://orcid.org/0000-0002-5930-9905, Vauzour, David ORCID: https://orcid.org/0000-0001-5952-8756 and Pontifex, Matthew G. ORCID: https://orcid.org/0000-0003-2174-2313 (2024) Menopause and Alzheimer’s disease susceptibility: Exploring the potential mechanisms. Brain Research, 1844. ISSN 1872-6240

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Abstract

Alzheimer’s Disease (AD), responsible for 62% of all dementia cases, is a progressive neurodegenerative condition that leads to cognitive dysfunction. The prevalence of AD is consistently higher in women suggesting they are disproportionately affected by this disease. Despite this, our understanding of this female AD vulnerability remains limited. Menopause has been identified as a potential contributing factor to AD in women, with earlier menopause onset associated with greater AD risk. However, the underlying mechanisms responsible for this increased risk are not fully understood. This review examines the potential role of menopause in the development of Alzheimer’s Disease providing a mechanistic overview of the available literature from hormones to pathology. While literature is now emerging that indicates a role of hormonal shifts, gut dysbiosis, lipid dysregulation and inflammation, more research is needed to fully elucidate the mechanisms involved.

Item Type:	Article
Additional Information:	Data availability statement: No data was used for the research described in the article.
Faculty \ School:	Faculty of Medicine and Health Sciences > School of Health Sciences Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User:	LivePure Connector
Date Deposited:	20 Aug 2024 13:30
Last Modified:	25 Sep 2024 18:02
URI:	https://ueaeprints.uea.ac.uk/id/eprint/96282
DOI:	10.1016/j.brainres.2024.149170

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