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ToolsMulligan, Angela A., Lentjes, Marleen A. H., Skinner, Jane and Welch, Ailsa A. (2024) The Dietary Inflammatory Index and its associations with biomarkers of nutrients with antioxidant potential, a biomarker of inflammation and multiple long-term conditions. Antioxidants, 13 (8). ISSN 2076-3921
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Abstract
We aimed to validate the Dietary Inflammatory Index (DII®) and assess the cross-sectional associations between the DII® and multiple long-term conditions (MLTCs) and biomarker concentrations and MLTCs using data from the European Prospective Investigation into Cancer (EPIC-Norfolk) study (11,113 men and 13,408 women). The development of MLTCs is associated with low-grade chronic inflammation, and ten self-reported conditions were selected for our MLTC score. Data from a validated FFQ were used to calculate energy-adjusted DII® scores. High-sensitivity C-reactive protein (hs-CRP) and circulating vitamins A, C, E, β-carotene and magnesium were available. Micronutrient biomarker concentrations were significantly lower as the diet became more pro-inflammatory (p-trend < 0.001), and hs-CRP concentrations were significantly higher in men (p-trend = 0.006). A lower DII® (anti-inflammatory) score was associated with 12–40% higher odds of MLTCs. Lower concentrations of vitamin C and higher concentrations of hs-CRP were associated with higher odds of MLTCs. The majority of the associations in our study between MLTCs, nutritional biomarkers, hs-CRP and the DII® were as expected, indicating that the DII® score has criterion validity. Despite this, a more anti-inflammatory diet was associated with higher odds of MLTCs, which was unexpected. Future studies are required to better understand the associations between MLTCs and the DII®.
| Item Type: | Article |
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| Additional Information: | Data Availability Statement: The authors will make the dataset available under a Data Transfer Agreement to any bona fide researcher who wishes to obtain the dataset in order to undertake a replication analysis. Although the dataset is anonymised, the breadth of the data included and the multiplicity of variables that are included in this analysis file as primary variables or confounding factors means that provision of the dataset to other researchers without a Data Transfer Agreement would constitute a risk. Requests for data sharing/access should be submitted to the EPIC Management Committee (epic-norfolk@mrc-epid.cam.ac.uk). Funding information: The EPIC-Norfolk study (DOI: 10.22025/2019.10.105.00004) has received funding from the Medical Research Council (G9502233, MR/N003284/1, MC-UU_12015/1 and MC_UU_00006/1) and Cancer Research UK (C864/A14136). |
| Uncontrolled Keywords: | antioxidant,biomarker,dietary inflammatory index,mltcs,mm,multi-morbidity,multiple long-term conditions,validation,food science,molecular biology,physiology,biochemistry,clinical biochemistry,cell biology,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1100/1106 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Population Health Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging |
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| Depositing User: | LivePure Connector |
| Date Deposited: | 14 Aug 2024 13:30 |
| Last Modified: | 14 Dec 2024 01:39 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/96251 |
| DOI: | 10.3390/antiox13080962 |
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