Tools
ToolsGale, Catharine R., Marioni, Riccardo E., Čukić, Iva, Chastin, Sebastien F., Dall, Philippa M., Dontje, Manon L., Skelton, Dawn A. and Deary, Ian J. and study on behalf of the Seniors USP Team (2018) The epigenetic clock and objectively measured sedentary and walking behavior in older adults: The Lothian Birth Cohort 1936. Clinical Epigenetics, 10. ISSN 1868-7075
Full text not available from this repository.Abstract
Background: Estimates of biological age derived from DNA-methylation patterns-known as the epigenetic clock-are associated with mortality, physical and cognitive function, and frailty, but little is known about their relationship with sedentary behavior or physical activity. We investigated the cross-sectional relationship between two such estimates of biological age and objectively measured sedentary and walking behavior in older people. Methods: Participants were 248 members of the Lothian Birth Cohort 1936. At age 79 years, sedentary behavior and physical activity were measured over 7 days using an activPAL activity monitor. Biological age was estimated using two measures of DNA methylation-based age acceleration-i.e., extrinsic and intrinsic epigenetic age acceleration. We used linear regression to assess the relationship between these two estimates of biological age and average daily time spent sedentary, number of sit-to-stand transitions, and step count. Results: Of the six associations examined, only two were statistically significant in initial models adjusted for age and sex alone. Greater extrinsic age acceleration was associated with taking fewer steps (regression coefficient (95% CI) - 0.100 (- 0.008, - 0.001), and greater intrinsic age acceleration was associated with making more sit-to-stand transitions (regression coefficient (95% CI) 0.006 (0.0001, 0.012). When we controlled for multiple statistical testing, neither of these associations survived correction (both P ≥ 0.17). Conclusion: In this cross-sectional study of 79-year-olds, we found no convincing evidence that biological age, as indexed by extrinsic or intrinsic epigenetic age acceleration, was associated with objectively measured sedentary or walking behavior.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: This work was supported by the Medical Research Council (MRC) as part of the Lifelong Health and Wellbeing Initiative [MR/K025023/1]. LBC1936 data collection is supported by the Disconnected Mind project (funded by Age UK and MRC [Mr/M01311/1 and G1001245/96077]) and undertaken within the University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology (funded by the BBSRC and MRC as part of the LLHW [MR/ K026992/1]). Methylation typing was supported by The Wellcome Trust Institutional Strategic Support Fund and the University of Edinburgh Gertrude Winifred Gear Fund. The funders played no part in the design of the study, collection, analysis, and interpretation of data or in writing the manuscript. Funding Information: IJD is supported by Age UK. PMD has received grant funding from PAL technologies outside the submitted work. The other authors declare that they have no competing interests. Publisher Copyright: © 2018 The Author(s). |
| Uncontrolled Keywords: | aging,epigenetic age,physical activity,sedentary behavior,molecular biology,genetics,developmental biology,genetics(clinical) ,/dk/atira/pure/subjectarea/asjc/1300/1312 |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 13 Aug 2024 08:30 |
| Last Modified: | 25 Sep 2024 18:01 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/96216 |
| DOI: | 10.1186/s13148-017-0438-z |
Actions (login required)
 |
View Item |