Paradigms of receptor kinase signaling in plants

Bender, Kyle W. and Zipfel, Cyril (2023) Paradigms of receptor kinase signaling in plants. Biochemical Journal, 480 (12). pp. 835-854. ISSN 0264-6021

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Abstract

Plant receptor kinases (RKs) function as key plasma-membrane localized receptors in the perception of molecular ligands regulating development and environmental response. Through the perception of diverse ligands, RKs regulate various aspects throughout the plant life cycle from fertilization to seed set. Thirty years of research on plant RKs has generated a wealth of knowledge on how RKs perceive ligands and activate downstream signaling. In the present review, we synthesize this body of knowledge into five central paradigms of plant RK signaling: (1) RKs are encoded by expanded gene families, largely conserved throughout land plant evolution; (2) RKs perceive many different kinds of ligands through a range of ectodomain architectures; (3) RK complexes are typically activated by co-receptor recruitment; (4) post-translational modifications fulfill central roles in both the activation and attenuation of RK-mediated signaling; and, (5) RKs activate a common set of downstream signaling processes through receptor-like cytoplasmic kinases (RLCKs). For each of these paradigms, we discuss key illustrative examples and also highlight known exceptions. We conclude by presenting five critical gaps in our understanding of RK function.

Item Type:	Article
Additional Information:	Funding Information: Funding for this work was provided by the Gatsby Charitable Foundation (to CZ), the European Research Council under the Grant Agreements No. 309858 and No. 773153 (grants ‘PHOSPHinnATE’ and ‘IMMUNO-PEPTALK’ to C.Z.), the University of Zürich (to C.Z.), a joint European Research Area Network for Coordinating Action in Plant Sciences (ERA-CAPS) grant (‘SICOPID’) from UK Research and Innovation (BB/ S004734/1 to C.Z.), and the Swiss National Science Foundation (grants 31003A_182625 and 310030_212382) (to C.Z.).
Faculty \ School:	Faculty of Science > The Sainsbury Laboratory
UEA Research Groups:	Faculty of Science > Research Groups > Plant Sciences
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	08 Aug 2024 14:30
Last Modified:	28 Sep 2024 00:01
URI:	https://ueaeprints.uea.ac.uk/id/eprint/96188
DOI:	10.1042/BCJ20220372

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