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Tammam, Mohamed A. and El-Demerdash, Amr 
ORCID: https://orcid.org/0000-0001-6459-2955
(2023)
Pederins, mycalamides, onnamides and theopederins: Distinctive polyketide families with intriguing therapeutic potentialities.
Current Research in Biotechnology, 6.
ISSN 2590-2628
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Abstract
In this comprehensive review article, an in-depth exploration over the period from 1949 to 2023 is presented, focusing on the discovery, chemistry, biosynthesis and therapeutic potentials of pederin and related polyketides. Herein, we extensively documented a diverse collection of 45 isolated compounds with varied chemical structures, systematically organized based on their isolation sources. Furthermore, it includes an updated detailed overview of their reported pharmacological activities whenever applicable. Additionally, the article briefly discusses insights into the proposed biosynthetic pathway of these intriguing polyketides.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: Amr El-Demerdash is immensely grateful to the John Innes Centre, Norwich Research Park, United Kingdom for the postdoctoral fellowship. Funding Information: Amr El-Demerdash is immensely grateful to his home university, Mansoura University, Egypt for the unlimited support inside and outside. Mohamed A. Tammam is humbly dedicating this work to the soul of his sister Dr. Mai A. Tammam who passed away on 19 of March 2022, she was always kind supporter in all aspects of his life. Publisher Copyright: © 2023 The Author(s) |
| Uncontrolled Keywords: | antifungal,antiviral,biosynthesis,cytotoxic,marine natural products,mycalamides,onnamides,pederins,pks-nrps,theopederins,biotechnology,sdg 14 - life below water ,/dk/atira/pure/subjectarea/asjc/1300/1305 |
| Faculty \ School: | Faculty of Science > School of Pharmacy (former - to 2024) |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 05 Aug 2024 14:30 |
| Last Modified: | 04 Nov 2024 00:54 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/96152 |
| DOI: | 10.1016/j.crbiot.2023.100145 |
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