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El-Demerdash, Amr 
ORCID: https://orcid.org/0000-0001-6459-2955, Moriou, Céline, Martin, Marie Thérèse, Rodrigues-Stien, Alice De Souza, Petek, Sylvain, Demoy-Schneider, Marina, Hall, Kathryn, Hooper, John N. A., Debitus, Cécile and Al-Mourabit, Ali
(2016)
Cytotoxic guanidine alkaloids from a French Polynesian Monanchora n. sp. sponge.
Journal of Natural Products, 79 (8).
pp. 1929-1937.
ISSN 0163-3864
Abstract
Four bicyclic and three pentacyclic guanidine alkaloids (1-7) were isolated from a French Polynesian Monanchora n. sp. sponge, along with the known alkaloids monalidine A (8), enantiomers 9-11 of known natural product crambescins, and the known crambescidins 12-15. Structures were assigned by spectroscopic data interpretation. The relative and absolute configurations of the alkaloids were established by analysis of 1H NMR and NOESY spectra and by circular dichroism analysis. The new norcrambescidic acid (7) corresponds to interesting biosynthetic variation within the pentacyclic core. All compounds exhibited antiproliferative and cytotoxic efficacy against KB, HCT116, HL60, MRC5, and B16F10 cancer cells, with IC50 values ranging from 4 nM to 10 μM.
| Item Type: | Article |
|---|---|
| Additional Information: | Publisher Copyright: © 2016 The American Chemical Society and American Society of Pharmacognosy. |
| Uncontrolled Keywords: | analytical chemistry,molecular medicine,pharmacology,pharmaceutical science,drug discovery,complementary and alternative medicine,organic chemistry,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1600/1602 |
| Faculty \ School: | Faculty of Science > School of Pharmacy (former - to 2024) |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 05 Aug 2024 11:34 |
| Last Modified: | 25 Sep 2024 17:59 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/96149 |
| DOI: | 10.1021/acs.jnatprod.6b00168 |
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