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El-Demerdash, Amr 
ORCID: https://orcid.org/0000-0001-6459-2955, Moriou, Céline, Martin, Marie Thérèse, Petek, Sylvain, Debitus, Cécile and Al-Mourabit, Ali
(2018)
Unguiculins A-C: Cytotoxic bis-guanidine alkaloids from the French Polynesian sponge, Monanchora n. sp.
Natural Product Research, 32 (13).
pp. 1512-1517.
ISSN 1478-6419
Abstract
Two new acyclic bis-guanidine alkaloids, unguiculins B-C (2–3), were isolated from a French Polynesian sponge Monanchora n. sp. together with the known compound unguiculin A (1). Their structures were established by spectroscopic data interpretation and comparison with the literature. Unguiculins A-C displayed antiproliferative and cytotoxic efficacy against several human cancer cells with IC50 values in the micromolar range.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: This work was supported by the mission sector of the Ministry of High Educationof the Arab Republic of Egypt (Egyptian Cultural Bureau in Paris), where Amr El-Demerdash’s Ph.D. was granted and completely funded. Financial support from CNRS-ICSN and IRD for the collection trip aboard R/V Alis. The French and French Polynesian governments for the Marquesas project, and ANR POMARE project, 2011-EBIM-006-01, are gratefully acknowledged. We thank F. Pelissier and O. Thoison for HPLC assistance. Special thanks for J.F. Gallard and K. Hammad for technical assistance and NMR measurements. We thank T. Cresteil and G. Aubert for cytotoxicity evaluations. Funding Information: This work was supported by the mission sector of the Ministry of High Educationof the Arab Republic of Egypt (Egyptian Cultural Bureau in Paris), where Amr El-Demerdash’s Ph.D. was granted and completely funded. Financial support from CNRS-ICSN and IRD for the collection trip aboard R/V Alis. The French and French Polynesian governments for the Marquesas project, and ANR POMARE project, 2011-EBIM-006-01, are gratefully acknowledged. Publisher Copyright: © 2017 Informa UK Limited, trading as Taylor & Francis Group. |
| Uncontrolled Keywords: | crambeidae,guanidine,monanchora,spermidine alkaloid,unguiculin,analytical chemistry,biochemistry,plant science,organic chemistry,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1600/1602 |
| Faculty \ School: | Faculty of Science > School of Pharmacy (former - to 2024) |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 05 Aug 2024 11:34 |
| Last Modified: | 25 Sep 2024 17:59 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/96148 |
| DOI: | 10.1080/14786419.2017.1385011 |
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