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El-Demerdash, Amr 
ORCID: https://orcid.org/0000-0001-6459-2955, Moriou, Céline, Toullec, Jordan, Besson, Marc, Soulet, Stéphanie, Schmitt, Nelly, Petek, Sylvain, Lecchini, David, Debitus, Cécile and Al-Mourabit, Ali
(2018)
Bioactive bromotyrosine-derived alkaloids from the polynesian sponge suberea ianthelliformis.
Marine Drugs, 16 (5).
ISSN 1660-3397
Abstract
Herein, we describe the isolation and spectroscopic identification of eight new tetrabrominated tyrosine alkaloids 2–9 from the Polynesian sponge Suberea ianthelliformis, along with known major compound psammaplysene D (1), N,N-dimethyldibromotyramine, 5-hydroxy xanthenuric acid, and xanthenuric acid. Cytotoxicity and acetylcholinesterase inhibition activities were evaluated for some of the isolated metabolites. They exhibited moderate antiproliferative activity against KB cancer cell lines, but psammaplysene D (1) displayed substantial cytotoxicity as well as acetylcholinesterase inhibition with IC50 values of 0.7 µM and 1.3 µM, respectively.
| Item Type: | Article |
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| Additional Information: | Funding Information: We thank the French Polynesian authorities, as well as the communities, for allowing us to collect in Marquesas Islands. Financial support from CNRS-ICSN, IRD for the collecting trip aboard R/V Alis, French and French Polynesian governments for the Marquesas and Biopolyval projects, ANR (POMARE project, 2011-EBIM-006-01), as well as project TASCMAR which is funded by the European Union under grant agreement number 634674. Labex MER and Labex CORAIL, are gratefully acknowledged. Amr El-Demerdash’s PhD was granted and financed by the Egyptian Government (Egyptian Cultural Bureau in Paris, Ministry of Higher Education), they are gratefully acknowledged. We thank IRD’s diving team (SEOH IRD Noumea, New Caledonia) and the R/V crew for their on-field help, O. Thoison for HPLC assistance J.-F. Gallard and K. Hammad for technical assistance and NMR measurements, J. Bignon for cytotoxicity evaluations. We gratefully acknowledge Laurent Calcul for the improvements to this manuscript. Publisher Copyright: © 2018 by the authors. |
| Uncontrolled Keywords: | acetylcholinesterase inhibition,brominated tyrosine alkaloids,cytotoxicity,suberea ianthelliformis,pharmaceutical science,drug discovery,pharmacology, toxicology and pharmaceutics (miscellaneous),sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/3000/3003 |
| Faculty \ School: | Faculty of Science > School of Pharmacy (former - to 2024) |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 05 Aug 2024 11:33 |
| Last Modified: | 12 Aug 2024 00:35 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/96146 |
| DOI: | 10.3390/md16050146 |
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