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Islam, Muhammad Torequl, Ali, Eunüs S., Uddin, Shaikh J., Shaw, Subrata, Islam, Md Amirul, Ahmed, Md Iqbal, Chandra Shill, Manik, Karmakar, Utpal Kumar, Yarla, Nagendra Sastry, Khan, Ishaq N., Billah, Md Morsaline, Pieczynska, Magdalena D., Zengin, Gokhan, Malainer, Clemens, Nicoletti, Ferdinando, Gulei, Diana, Berindan-Neagoe, Ioana, Apostolov, Apostol, Banach, Maciej, Yeung, Andy W. K., El-Demerdash, Amr 
ORCID: https://orcid.org/0000-0001-6459-2955, Xiao, Jianbo, Dey, Prasanta, Yele, Santosh, Jóźwik, Artur, Strzałkowska, Nina, Marchewka, Joanna, Rengasamy, Kannan R. R., Horbańczuk, Jarosław, Kamal, Mohammad Amjad, Mubarak, Mohammad S., Mishra, Siddhartha K., Shilpi, Jamil A. and Atanasov, Atanas G.
(2018)
Phytol: A review of biomedical activities.
Food and Chemical Toxicology, 121.
pp. 82-94.
ISSN 0278-6915
Abstract
Phytol (PYT) is a diterpene member of the long-chain unsaturated acyclic alcohols. PYT and some of its derivatives, including phytanic acid (PA), exert a wide range of biological effects. PYT is a valuable essential oil (EO) used as a fragrance and a potential candidate for a broad range of applications in the pharmaceutical and biotechnological industry. There is ample evidence that PA may play a crucial role in the development of pathophysiological states. Focusing on PYT and some of its most relevant derivatives, here we present a systematic review of reported biological activities, along with their underlying mechanism of action. Recent investigations with PYT demonstrated anxiolytic, metabolism-modulating, cytotoxic, antioxidant, autophagy- and apoptosis-inducing, antinociceptive, anti-inflammatory, immune-modulating, and antimicrobial effects. PPARs- and NF-κB-mediated activities are also discussed as mechanisms responsible for some of the bioactivities of PYT. The overall goal of this review is to discuss recent findings pertaining to PYT biological activities and its possible applications.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: AGA acknowledges the support by the Polish KNOW (Leading National Research Centre) Scientific Consortium “Healthy Animal—Safe Food,” decision of Ministry of Science and Higher Education No. 05-1/KNOW2/2015 . Publisher Copyright: © 2018 Elsevier Ltd |
| Uncontrolled Keywords: | biological activities,phytanic acid,phytol,phytol metabolites,plant-derived compounds,food science,toxicology ,/dk/atira/pure/subjectarea/asjc/1100/1106 |
| Faculty \ School: | Faculty of Science > School of Pharmacy (former - to 2024) |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 05 Aug 2024 11:33 |
| Last Modified: | 25 Sep 2024 17:59 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/96144 |
| DOI: | 10.1016/j.fct.2018.08.032 |
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