Chemical diversity and biological activities of marine sponges of the genus Suberea: A systematic review

El-Demerdash, Amr ORCID: https://orcid.org/0000-0001-6459-2955, Atanasov, Atanas G., Horbanczuk, Olaf K., Tammam, Mohamed A., Abdel-Mogib, Mamdouh, Hooper, John N. A., Sekeroglu, Nazim, Al-Mourabit, Ali and Kijjoa, Anake (2019) Chemical diversity and biological activities of marine sponges of the genus Suberea: A systematic review. Marine Drugs, 17 (2). ISSN 1660-3397

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Abstract

Marine natural products (MNPs) continue to be in the spotlight in the global drug discovery endeavor. Currently, more than 30,000 structurally diverse secondary metabolites from marine sources have been isolated, making MNPs a profound, renewable source to investigate novel drug compounds. Marine sponges of the genus Suberea (family: Aplysinellidae) are recognized as producers of bromotyrosine derivatives, which are considered distinct chemotaxonomic markers for the marine sponges belonging to the order Verongida. This class of compounds exhibits structural diversity, ranging from simple monomeric molecules to more complex molecular scaffolds, displaying a myriad of biological and pharmacological potentialities. In this review, a comprehensive literature survey covering the period of 1998-2018, focusing on the chemistry and biological/pharmacological activities of marine natural products from marine sponges of the genus Suberea, with special attention to the biogenesis of the different skeletons of halogenated compounds, is presented.

Item Type:	Article
Additional Information:	Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Uncontrolled Keywords:	bioactivities,biosynthesis,bromotyrosine derivatives,marine sponges,suberea,verongida,pharmaceutical science,drug discovery,pharmacology, toxicology and pharmaceutics (miscellaneous),sdg 7 - affordable and clean energy,sdg 14 - life below water ,/dk/atira/pure/subjectarea/asjc/3000/3003
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024)
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	05 Aug 2024 11:33
Last Modified:	25 Sep 2024 17:59
URI:	https://ueaeprints.uea.ac.uk/id/eprint/96140
DOI:	10.3390/md17020115

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