Utilization of 5-chloro-2-(cyanoacetamido)pyridines in the synthesis of biologically active heterocyclic hybrids

Abdel-Latif, Ehab, Alashhab, Rabia E., El-Demerdash, Amr ORCID: https://orcid.org/0000-0001-6459-2955 and Ismail, Mohamed A. (2020) Utilization of 5-chloro-2-(cyanoacetamido)pyridines in the synthesis of biologically active heterocyclic hybrids. ChemistrySelect, 5 (5). pp. 1797-1802. ISSN 2365-6549

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Abstract

A simple synthesis for a series of chloropyridine derivatives incorporating heterocyclic hybrids has been accomplished. The key reaction involving employment of 5-chloro-2-(cyanoacetamido)pyridines 3 in the synthesis of chloropyridinyl-pyridone, chloropyridinyl-pyrazole, chloropyridinyl-thiazole and chloropyridinyl-thiophene hybrids. The newly synthesized heterocycles were evaluated for their antioxidant and antibacterial activities against Gram-positive and Gram-negative bacterial strains. 3-Amino-N-(3,5-dichloropyridin-2-yl)-1H-pyrazole-4-carboxamide (12 b) was found to be the most potent compound against Escherichia coli and Staphylococcus aureus exhibiting inhibition percent of 92.3 % and 100 %, respectively, when compared to the standard drug ampicillin. Moreover, compound 12 b displayed the most significant antioxidant activity with percent inhibition 87.8 % which is close to the antioxidant activity of ascorbic acid.

Item Type:	Article
Uncontrolled Keywords:	2-amino-5-chloropyridine,antibacterial,phenyl isothiocyanate,pyridinyl hybrids,chemistry(all) ,/dk/atira/pure/subjectarea/asjc/1600
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024)
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	05 Aug 2024 11:33
Last Modified:	25 Sep 2024 17:59
URI:	https://ueaeprints.uea.ac.uk/id/eprint/96136
DOI:	10.1002/slct.201904051

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