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Tammam, Mohamed A., Gamal El-Din, Mariam I., Abood, Amira and El-Demerdash, Amr 
ORCID: https://orcid.org/0000-0001-6459-2955
(2023)
Recent advances in the discovery, biosynthesis, and therapeutic potential of isocoumarins derived from fungi: A comprehensive update.
RSC Advances, 13 (12).
pp. 8049-8089.
ISSN 2046-2069
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Abstract
Microorganisms still remain the main hotspots in the global drug discovery avenue. In particular, fungi are highly prolific producers of vast structurally diverse specialized secondary metabolites, which have displayed a myriad of biomedical potentials. Intriguingly, isocoumarins is one distinctive class of fungal natural products polyketides, which demonstrated numerous remarkable biological and pharmacological activities. This review article provides a comprehensive state-of-the-art over the period 2000-2022 about the discovery, isolation, classifications, and therapeutic potentials of isocoumarins exclusively reported from fungi. Indeed, a comprehensive list of 351 structurally diverse isocoumarins were documented and classified according to their fungal sources [16 order/28 family/55 genera] where they have been originally discovered along with their reported pharmacological activities wherever applicable. Also, recent insights around their proposed and experimentally proven biosynthetic pathways are also briefly discussed.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: Amr El-Demerdash is immensely grateful to the John Innes Centre, Norwich Research Park, United Kingdom for the postdoctoral fellowship. Amr El-Demerdash is thankful to his home university, Mansoura University, Egypt for the unlimited support, inside and outside. Mohamed A. Tammam is humbly dedicating this work to the soul of his sister Dr Mai A. Tammam who passed away on 19 of March 2022, she was always kind supporter in all aspects of my life. Publisher Copyright: © 2023 The Royal Society of Chemistry. |
| Uncontrolled Keywords: | chemistry(all),chemical engineering(all) ,/dk/atira/pure/subjectarea/asjc/1600 |
| Faculty \ School: | Faculty of Science > School of Pharmacy (former - to 2024) |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 05 Aug 2024 11:31 |
| Last Modified: | 12 Aug 2024 09:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/96125 |
| DOI: | 10.1039/d2ra08245d |
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