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Hayward, Deanne, Goddard, Zoë R. 
ORCID: https://orcid.org/0000-0002-7900-1553, Cominetti, Marco M. D., Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Beekman, Andrew M. ORCID: https://orcid.org/0000-0002-3056-6406
(2024)
Light-activated azobenzene peptide inhibitor of the PD-1/PD-L1 interaction.
Chemical Communications, 60 (63).
pp. 8228-8231.
ISSN 1359-7345
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Abstract
Inhibiting the PD-1/PD-L1 protein–protein interaction is a key immunotherapy for cancer. Antibodies dominate the clinical space but are costly, with limited applicability and immune side effects. We developed a photo-controlled azobenzene peptide that selectively inhibits the PD-1/PD-L1 interaction when in the cis isomer only. Activity is demonstrated in in vitro and cellular assays.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding information: The authors acknowledge support from Big C Cancer Charity (19-13R) and the Royal Society (RGS\R1\201008). Mass spectrometry was supported by BBSRC (BB/T017708/1). |
| Uncontrolled Keywords: | electronic, optical and magnetic materials,ceramics and composites,metals and alloys,materials chemistry,surfaces, coatings and films,chemistry(all),catalysis,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2500/2504 |
| Faculty \ School: | Faculty of Science Faculty of Science > School of Pharmacy (former - to 2024) |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 16 Jul 2024 08:32 |
| Last Modified: | 14 Aug 2024 03:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/95933 |
| DOI: | 10.1039/D4CC01249F |
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