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Merinopoulos, Ioannis, Bhalraam, U., Kasmai, Bahman, Hewson, David, Greenwood, Richard, Eccleshall, Simon C., Smith, James 
ORCID: https://orcid.org/0000-0003-0427-8678, Tsampasian, Vasiliki and Vassiliou, Vassilios ORCID: https://orcid.org/0000-0002-4005-7752
(2024)
Myocardial inflammation after elective percutaneous coronary intervention.
Hellenic Journal of Cardiology.
ISSN 1109-9666
Abstract
Background: It is well established that inflammation plays a central role in the sequalae of percutaneous coronary intervention (PCI). Most of the studies to date have focused on the inflammatory reaction affecting the vessel wall post angioplasty. However, there are data to suggest that the main foci of inflammation are in fact in the myocardium beyond the vessel wall. The main aim of our study was to investigate the myocardial inflammation post elective, uncomplicated angioplasty with cardiovascular magnetic resonance (CMR) enhanced by ultrasmall superparamagnetic particles of iron oxide (USPIO) and also blood biomarkers. This is the first study to report such findings post elective angioplasty. Methods: We assessed patients undergoing elective angioplasty for stable angina with USPIO-enhanced CMR two weeks later and compared the results to those of healthy volunteers utilised as a control group. We excluded patients with previous myocardial infarction, previous PCI or any significant inflammatory condition. All patients also underwent blood biomarker testing at baseline (pre-PCI), 4 hours and 2 weeks later. Results: A total of five patients and three controls were scanned. There was a small absolute increase, although statistically not significant, in R2* values in the PCI area compared with either remote myocardium from same patient (PCI area (LAD) vs remote myocardium (Cx) (19.3 ± 10.8 vs 9.2±7.9, p =0.1)) or healthy myocardium from healthy volunteers (PCI area (LAD) vs healthy myocardium (LAD) (19.3 ± 10.8 vs 12.2 ± 4.0, p = 0.2)). PTX3 and IL6 were the only biomarkers that changed significantly from baseline to 4 hours to 2 weeks. Both biomarkers peaked at 4 hours. Conclusion: We have utilised USPIO-enhanced CMR for the first time, to assess myocardial inflammation post elective, uncomplicated PCI. We have demonstrated a small, numerical increase in inflammation which was not statistically significant. This first study opens the way for future studies to use this method as an endpoint for inflammation targeting.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre |
| Depositing User: | LivePure Connector |
| Date Deposited: | 02 Jul 2024 10:32 |
| Last Modified: | 07 Jul 2024 06:35 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/95754 |
| DOI: | 10.1016/j.hjc.2024.06.010 |
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