The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin

Romanowski, Piotr, Madine, Mark A., Rowles, Alison, Blow, J. Julian ORCID: https://orcid.org/0000-0002-9524-5849 and Laskey, Ronald A. (1996) The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin. Current Biology, 6 (11). pp. 1416-1425. ISSN 0960-9822

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Abstract

The origin recognition complex (ORC) and the minichromosome maintenance (MCM) protein complex were initially discovered in yeast and shown to be essential for DNA replication. Homologues of ORC and MCM proteins exist in higher eukaryotes, including Xenopus. The Xenopus MCM proteins and the Xenopus homologues of Saccharomyces cerevisiae Orc 1p and Orc2p (XOrc1 and XOrc2) have recently been shown to be essential for DNA replication. Here, we describe the different but interdependent functions of the ORC and MCM complexes in DNA replication in Xenopus egg extracts.

Item Type:	Article
Faculty \ School:
Depositing User:	LivePure Connector
Date Deposited:	11 Jun 2024 10:31
Last Modified:	25 Sep 2024 17:52
URI:	https://ueaeprints.uea.ac.uk/id/eprint/95566
DOI:	10.1016/S0960-9822(96)00746-4

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