Cell cycle control of replication initiation in eukaryotes

Chevalier, Stephane and Blow, J. Julian (1996) Cell cycle control of replication initiation in eukaryotes. Current Opinion in Cell Biology, 8 (6). pp. 815-821. ISSN 0955-0674

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Abstract

Studies on the initiation of DNA replication in eukaryotes have progressed recently through different approaches that promise to converge. Proteins interacting with the origin recognition complex form a prereplicative complex early in the cell cycle. The regulation of the binding of MCM/P1 proteins to chromatin plays a key role in the replication licensing system which prevents re-replication in a single cell cycle. Cyclin-dependent kinases provide an overall control of the cell cycle by stimulating S-phase entry and possibly by preventing re-establishment of prereplicative complexes in G2 phase.

Item Type: Article
Faculty \ School:
Depositing User: LivePure Connector
Date Deposited: 11 Jun 2024 09:30
Last Modified: 11 Jun 2024 09:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/95538
DOI: 10.1016/S0955-0674(96)80082-2

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