RNA polymerase IV directs silencing of endogenous DNA

Herr, A. J., Jensen, M. B., Dalmay, T. and Baulcombe, D. C. (2005) RNA polymerase IV directs silencing of endogenous DNA. Science, 308 (5718). pp. 118-120. ISSN 0036-8075

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Abstract

Plants encode subunits for a fourth RNA polymerase (Pol IV) in addition to the well-known DNA-dependent RNA polymerases I, II, and III. By mutation of the two largest subunits (NRPD1a and NRPD2), we show that Pol IV silences certain transposons and repetitive DNA in a short interfering RNA pathway involving RNA-dependent RNA polymerase 2 and Dicer-like 3. The existence of this distinct silencing polymerase may explain the paradoxical involvement of an RNA silencing pathway in maintenance of transcriptional silencing.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Biological Sciences
UEA Research Groups:	Faculty of Science > Research Groups > Plant Sciences
Depositing User:	EPrints Services
Date Deposited:	01 Oct 2010 13:37
Last Modified:	06 Feb 2025 03:14
URI:	https://ueaeprints.uea.ac.uk/id/eprint/955
DOI:	10.1126/science.1106910

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