Blow, J. Julian ORCID: https://orcid.org/0000-0002-9524-5849 and Gillespie, Peter J.
(2008)
Replication licensing and cancer: a fatal entanglement?
Nature Reviews Cancer, 8 (10).
pp. 799-806.
ISSN 1474-175X
Abstract
Correct regulation of the replication licensing system ensures that chromosomal DNA is precisely duplicated in each cell division cycle. Licensing proteins are inappropriately expressed at an early stage of tumorigenesis in a wide variety of cancers. Here we discuss evidence that misregulation of replication licensing is a consequence of oncogene-induced cell proliferation. This misregulation can cause either under-or over-replication of chromosomal DNA, and could explain the genetic instability commonly seen in cancer cells.
Item Type: | Article |
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Uncontrolled Keywords: | animals,cell cycle proteins,cell transformation,neoplastic,dna damage,dna replication,humans,mice,neoplasms,nuclear proteins,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
Faculty \ School: | |
Depositing User: | LivePure Connector |
Date Deposited: | 10 Jun 2024 15:31 |
Last Modified: | 22 Aug 2024 11:37 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/95491 |
DOI: | 10.1038/nrc2500 |
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