Replication licensing and cancer: a fatal entanglement?

Blow, J. Julian and Gillespie, Peter J. (2008) Replication licensing and cancer: a fatal entanglement? Nature Reviews Cancer, 8 (10). pp. 799-806. ISSN 1474-175X

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Abstract

Correct regulation of the replication licensing system ensures that chromosomal DNA is precisely duplicated in each cell division cycle. Licensing proteins are inappropriately expressed at an early stage of tumorigenesis in a wide variety of cancers. Here we discuss evidence that misregulation of replication licensing is a consequence of oncogene-induced cell proliferation. This misregulation can cause either under-or over-replication of chromosomal DNA, and could explain the genetic instability commonly seen in cancer cells.

Item Type:	Article
Uncontrolled Keywords:	animals,cell cycle proteins,cell transformation,neoplastic,dna damage,dna replication,humans,mice,neoplasms,nuclear proteins,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:
Depositing User:	LivePure Connector
Date Deposited:	10 Jun 2024 15:31
Last Modified:	17 Jun 2024 00:18
URI:	https://ueaeprints.uea.ac.uk/id/eprint/95491
DOI:	10.1038/nrc2500

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