The chromosome cycle: coordinating replication and segregation

Blow, J. Julian ORCID: https://orcid.org/0000-0002-9524-5849 and Tanaka, Tomoyuki U. (2005) The chromosome cycle: coordinating replication and segregation. EMBO Reports, 6 (11). pp. 1028-1034. ISSN 1469-221X

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Abstract

During the cell-division cycle, chromosomal DNA must initially be precisely duplicated and then correctly segregated to daughter cells. The accuracy of these two events is maintained by two interlinked cycles: the replication licensing cycle, which ensures precise duplication of DNA, and the cohesion cycle, which ensures correct segregation. Here we provide a general overview of how these two systems are coordinated to maintain genetic stability during the cell cycle.

Item Type:	Article
Additional Information:	Second in the Cycles review series
Uncontrolled Keywords:	cell cycle,cohesion,dna replication,replication licensing
Faculty \ School:
Depositing User:	LivePure Connector
Date Deposited:	10 Jun 2024 15:31
Last Modified:	18 Jun 2026 20:14
URI:	https://ueaeprints.uea.ac.uk/id/eprint/95481
DOI:	10.1038/sj.embor.7400557

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