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Li, Anatoliy and Blow, J. Julian 
ORCID: https://orcid.org/0000-0002-9524-5849
(2004)
Negative regulation of geminin by CDK-dependent ubiquitination controls replication licensing.
Cell Cycle, 3 (4).
pp. 441-443.
ISSN 1538-4101
Abstract
The replication licensing system ensures the precise duplication of chromosomal DNA in each cell cycle. In metazoans, a small protein called geminin plays a central role in negatively regulating licensing late in the cell cycle. Recent work using Xenopus egg extracts shows how geminin activity is downregulated on exit from metaphase in a process that requires mitotic cyclin-dependent kinases (CDKs). Geminin is polyubiquitinated by the Anaphase Promoting Complex, but instead of being proteolysed-the normal fate of polyubiquitinated proteins-much of the geminin is deubiquitinated, leaving it inactive. These results suggest a simple model for how precise chromosome duplication is ensured in the Xenopus model system.
| Item Type: | Article |
|---|---|
| Faculty \ School: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 10 Jun 2024 15:31 |
| Last Modified: | 25 Sep 2024 17:52 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/95474 |
| DOI: | 10.4161/cc.3.4.816 |
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