Buffered qualitative stability explains the robustness and evolvability of transcriptional networks

Albergante, Luca, Blow, J. Julian ORCID: https://orcid.org/0000-0002-9524-5849 and Newman, Timothy J. (2014) Buffered qualitative stability explains the robustness and evolvability of transcriptional networks. eLife, 3. ISSN 2050-084X

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Abstract

The gene regulatory network (GRN) is the central decision-making module of the cell. We have developed a theory called Buffered Qualitative Stability (BQS) based on the hypothesis that GRNs are organised so that they remain robust in the face of unpredictable environmental and evolutionary changes. BQS makes strong and diverse predictions about the network features that allow stable responses under arbitrary perturbations, including the random addition of new connections. We show that the GRNs of E. coli, M. tuberculosis, P. aeruginosa, yeast, mouse, and human all verify the predictions of BQS. BQS explains many of the small- and large-scale properties of GRNs, provides conditions for evolvable robustness, and highlights general features of transcriptional response. BQS is severely compromised in a human cancer cell line, suggesting that loss of BQS might underlie the phenotypic plasticity of cancer cells, and highlighting a possible sequence of GRN alterations concomitant with cancer initiation.

Item Type:	Article
Additional Information:	Copyright © 2014, Albergante et al.
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:
Depositing User:	LivePure Connector
Date Deposited:	10 Jun 2024 15:30
Last Modified:	25 Sep 2024 17:51
URI:	https://ueaeprints.uea.ac.uk/id/eprint/95462
DOI:	10.7554/eLife.02863.001

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