How dormant origins promote complete genome replication

Blow, J. Julian, Ge, Xin Quan and Jackson, Dean A. (2011) How dormant origins promote complete genome replication. Trends in Biochemical Sciences, 36 (8). pp. 405-414. ISSN 0968-0004

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Abstract

Many replication origins that are licensed by loading MCM2-7 complexes in G1 are not normally used. Activation of these dormant origins during S phase provides a first line of defence for the genome if replication is inhibited. When replication forks fail, dormant origins are activated within regions of the genome currently engaged in replication. At the same time, DNA damage-response kinases activated by the stalled forks preferentially suppress the assembly of new replication factories, thereby ensuring that chromosomal regions experiencing replicative stress complete synthesis before new regions of the genome are replicated. Mice expressing reduced levels of MCM2-7 have fewer dormant origins, are cancer-prone and are genetically unstable, demonstrating the importance of dormant origins for preserving genome integrity. We review the function of dormant origins, the molecular mechanism of their regulation and their physiological implications.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:
Depositing User:	LivePure Connector
Date Deposited:	10 Jun 2024 10:32
Last Modified:	17 Jun 2024 00:18
URI:	https://ueaeprints.uea.ac.uk/id/eprint/95444
DOI:	10.1016/j.tibs.2011.05.002

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