A role for dormant origins in tumor suppression

Klotz-Noack, Kathleen and Blow, J. Julian ORCID: https://orcid.org/0000-0002-9524-5849 (2011) A role for dormant origins in tumor suppression. Molecular Cell, 41 (5). pp. 495-496. ISSN 1097-2765

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Abstract

In this issue of Molecular Cell, Kawabata et al. (2011) show that mice hypomorphic for the replication licensing protein Mcm4 show spontaneous DNA replication defects due to a lack of dormant origins, potentially explaining why these mice are cancer prone.

Item Type:	Article
Uncontrolled Keywords:	replicative stress,excess mcm2-7,cancer,mice,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:
Depositing User:	LivePure Connector
Date Deposited:	10 Jun 2024 10:31
Last Modified:	18 Jun 2026 20:13
URI:	https://ueaeprints.uea.ac.uk/id/eprint/95440
DOI:	10.1016/j.molcel.2011.02.014

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