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del Valle, Carla Arnau, Thomas, Paul, Galindo, Francisco, Muñoz-Herranz, M. Paz 
ORCID: https://orcid.org/0000-0001-9037-349X and Marín, María J. ORCID: https://orcid.org/0000-0001-8021-5498
(2024)
Gold nanoparticle-based two-photon fluorescent nanoprobe for monitoring intracellular nitric oxide levels.
Photodiagnosis and Photodynamic Therapy, 46.
ISSN 1572-1000
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Abstract
Significance Nitric oxide (NO) is involved in the regulation of physiological and pathological mechanisms of the cardiovascular, nervous and immune systems; and plays an important role in cancer being involved in tumor growth and suppressing processes depending on its concentration. Approach The development of a near-infrared excitable nanoprobe, consisting of gold nanoparticles functionalized with a two-photon excitable NO probe, for the detection of intracellular NO is reported. Results The nanoprobe showed good selectivity towards NO over cellular interferences and excellent stability in aqueous-medium over time. The nanoprobe was able to selectively detect endogenous and exogenous NO in different cell lines and it accumulated in the acidic organelles showing negligible toxicity. Importantly, the nanoprobe showed potential to quantify intracellular NO concentrations in breast cancer cells. Conclusions The novel gold-based two-photon nanoprobe showed an excellent performance and versatility and could potentially be applied for the spatiotemporal monitoring of in vivo NO levels.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
| Faculty \ School: | Faculty of Science > School of Pharmacy (former - to 2024) Faculty of Science Faculty of Science > School of Chemistry (former - to 2024) |
| UEA Research Groups: | Faculty of Science > Research Groups > Chemistry of Materials and Catalysis Faculty of Science > Research Groups > Centre for Photonics and Quantum Science Faculty of Science > Research Groups > Chemistry of Life Processes Faculty of Science > Research Groups > Chemistry of Light and Energy |
| Depositing User: | LivePure Connector |
| Date Deposited: | 30 May 2024 08:31 |
| Last Modified: | 20 Dec 2024 01:11 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/95335 |
| DOI: | 10.1016/j.pdpdt.2024.104182 |
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