Myocardial scar and remodelling predict long-term mortality in severe aortic stenosis beyond 10 years

Thornton, George D., Vassiliou, Vassilios S. ORCID: https://orcid.org/0000-0002-4005-7752, Musa, Tarique A., Aziminia, Nikoo, Craig, Neil, Dattani, Abhishek, Davies, Rhodri H., Captur, Gabriella, Moon, James C., Dweck, Marc R., Myerson, Saul G., Prasad, Sanjay K., McCann, Gerry P., Greenwood, John P., Singh, Anvesha and Treibel, Thomas A. and BSCMR AS700 Consortium (2024) Myocardial scar and remodelling predict long-term mortality in severe aortic stenosis beyond 10 years. European Heart Journal, 45 (22). 2019–2022. ISSN 0195-668X

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Abstract

Aortic stenosis (AS) is characterized by the narrowing of the aortic valve and compensatory myocardial remodelling.1 However, ultimately the left ventricle decompensates, leading to heart failure and death, and intervention is advised for severe AS accompanied by either symptoms or left ventricular (LV) dysfunction.2 Yet, over half of patients receiving aortic valve replacement (AVR) have irreversible myocardial scarring.3 Our multi-centre UK consortium linked pre-operative myocardial scarring, detected by late gadolinium enhancement (LGE) on cardiovascular magnetic resonance (CMR) with increased all-cause and cardiovascular (CV) mortality, regardless of intervention type, after a median of 3.5 years.4 With the integration of machine learning for CMR analysis, we achieve 40% greater precision than human assessment, potentially uncovering patterns obscured by human variability.5 We now examine whether the association of myocardial scar with mortality persists over longer-term follow-up.

Item Type:	Article
Additional Information:	Data Availability Statement: Data is available on request. Funding Information: This study was in part supported by the British Heart Foundation (University of Leeds, Prof Greenwood [PG/11/126/29321]; University of Leicester, Prof McCann [PG/07/068/2334]; University of Oxford, Prof Myerson [FS/10/015/28104]; University of Edinburgh, Dr Dweck [FS/10/026]; University College London, Prof Moon [FS/08/028/24767]), Dr Treibel [FS/19/35/34374], Dr Thornton [FS/CRTF/21/2412] and the National Institute for Health Research (University College London, Dr Treibel [DRF-2013-06-102]), including via its Biomedical Research Centre and Clinical Research Facility programmes, as well as Rosetrees Trust. The views expressed are those of the authors and not necessarily those of the UK National Health Service, National Institute for Health Research, or Department of Health.
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	LivePure Connector
Date Deposited:	28 May 2024 16:31
Last Modified:	11 Jun 2024 09:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/95325
DOI:	10.1093/eurheartj/ehae067

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