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Rowland, Samantha N., O'Donnell, Emma, James, Lewis J., Da Boit, Mariasole, Fujii, Naoto, Arnold, Josh T. 
ORCID: https://orcid.org/0000-0001-9905-2000, Lloyd, Alex B., Eglin, Clare M., Shepherd, Anthony I. and Bailey, Stephen J.
(2024)
Nitrate ingestion blunts the increase in blood pressure during cool air exposure. A double-blind, placebo-controlled, randomized, crossover trial.
Journal of Applied Physiology, 136 (6).
pp. 1364-1375.
ISSN 8750-7587
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Abstract
Cold exposure increases blood pressure (BP) and salivary flow rate (SFR). Increased cold-induced SFR would be hypothesized to enhance oral nitrate delivery for reduction to nitrite by oral anaerobes and to subsequently elevate plasma [nitrite] and nitric oxide bioavailability. We tested the hypothesis that dietary nitrate supplementation would increase plasma [nitrite] and lower BP to a greater extent in cool compared with normothermic conditions. Twelve males attended the laboratory on four occasions. Baseline measurements were completed at 28°C. Subsequently, participants ingested 140 mL of concentrated nitrate-rich (BR; ∼13 mmol nitrate) or nitrate-depleted (PL) beetroot juice. Measurements were repeated over 3 h at either 28°C (Norm) or 20°C (Cool). Mean skin temperature was lowered compared with baseline in PL-Cool and BR-Cool. SFR was greater in BR-Norm, PLCool, and BR-Cool than PL-Norm. Plasma [nitrite] at 3 h was higher in BR-Cool (592 ± 239 nM) versus BR-Norm (410 ± 195 nM). Systolic BP (SBP) at 3 h was not different between PL-Norm (117 ± 6 mmHg) and BR-Norm (113 ± 9 mmHg). SBP increased above baseline at 1, 2, and 3 h in PL-Cool but not BR-Cool. These results suggest that BR consumption is more effective at increasing plasma [nitrite] in cool compared with normothermic conditions and blunts the rise in BP following acute cool air exposure, which might have implications for attenuating the increased cardiovascular strain in the cold.
| Item Type: | Article |
|---|---|
| Additional Information: | Data availability statement: The data for this study are openly available and can be accessed at: https://doi.org/10.17028/rd.lboro.24020796. Funding information: This research was supported by the National Institute for Health and Care Research (NIHR) Leicester Biomedical Research Centre. |
| Uncontrolled Keywords: | beetroot,cardiovascular strain,inorganic nitrate,nitric oxide,thermoregulation,medicine(all) ,/dk/atira/pure/subjectarea/asjc/2700 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 25 Apr 2024 15:30 |
| Last Modified: | 25 Sep 2024 17:46 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/95018 |
| DOI: | 10.1152/japplphysiol.00593.2023 |
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