Resisting death by metal:metabolism and Cu/Zn homeostasis in bacteria

Sullivan, Matthew J. ORCID:, Terán, Ignacio, Goh, Kelvin G.K. and Ulett, Glen C. (2024) Resisting death by metal:metabolism and Cu/Zn homeostasis in bacteria. Emerging Topics in Life Sciences, 8 (1). pp. 45-56. ISSN 2397-8554

[thumbnail of etls-2023-0115c]
PDF (etls-2023-0115c) - Published Version
Available under License Creative Commons Attribution.

Download (1MB) | Preview


Metal ions such as zinc and copper play important roles in host-microbe interactions and their availability can drastically affect the survival of pathogenic bacteria in a host niche. Mechanisms of metal homeostasis protect bacteria from starvation, or intoxication, defined as when metals are limiting, or in excess, respectively. In this mini-review, we summarise current knowledge on the mechanisms of resistance to metal stress in bacteria, focussing specifically on the homeostasis of cellular copper and zinc. This includes a summary of the factors that subvert metal stress in bacteria, which are independent of metal efflux systems, and commentary on the role of small molecules and metabolic systems as important mediators of metal resistance.

Item Type: Article
Additional Information: Funding Information: This work was supported by the National Health and Medical Research Council (Australia) grant to G.C.U., M.J. S. and K.G.K.G. [APP2021475], a Royal Society Research Grant to M.J.S. [RGS\R1\231151] and Medical Research Council (U.K.) funding for a Microbes, Microbiomes and Bioinformatics Doctoral Training Partnership (MMB-DTP) PhD scholarship to I.T. Publisher Copyright: © 2024 The Author(s).
Uncontrolled Keywords: medicine(all) ,/dk/atira/pure/subjectarea/asjc/2700
Faculty \ School: Faculty of Science > School of Biological Sciences
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 16 Apr 2024 12:31
Last Modified: 16 Apr 2024 12:31
DOI: 10.1042/ETLS20230115


Downloads per month over past year

Actions (login required)

View Item View Item