Structural mechanisms of mitochondrial uncoupling protein 1 regulation in thermogenesis

Jones, Scott A., Ruprecht, Jonathan J., Crichton, Paul G. ORCID: and Kunji, Edmund R.S. (2024) Structural mechanisms of mitochondrial uncoupling protein 1 regulation in thermogenesis. Trends in Biochemical Sciences. ISSN 0968-0004

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In mitochondria, the oxidation of nutrients is coupled to ATP synthesis by the generation of a protonmotive force across the mitochondrial inner membrane. In mammalian brown adipose tissue (BAT), uncoupling protein 1 (UCP1, SLC25A7), a member of the SLC25 mitochondrial carrier family, dissipates the protonmotive force by facilitating the return of protons to the mitochondrial matrix. This process short-circuits the mitochondrion, generating heat for non-shivering thermogenesis. Recent cryo-electron microscopy (cryo-EM) structures of human UCP1 have provided new molecular insights into the inhibition and activation of thermogenesis. Here, we discuss these structures, describing how purine nucleotides lock UCP1 in a proton-impermeable conformation and rationalizing potential conformational changes of this carrier in response to fatty acid activators that enable proton leak for thermogenesis.

Item Type: Article
Additional Information: Publisher Copyright: © 2024 The Author(s)
Uncontrolled Keywords: bioenergetics,brown adipose tissue,non-shivering thermogenesis,slc25 mitochondrial carrier family,thermogenin,ucp1,biochemistry,molecular biology ,/dk/atira/pure/subjectarea/asjc/1300/1303
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 16 Apr 2024 12:30
Last Modified: 16 Apr 2024 12:31
DOI: 10.1016/j.tibs.2024.03.005

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