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Jones, Scott A., Ruprecht, Jonathan J., Crichton, Paul G. 
ORCID: https://orcid.org/0000-0003-3786-8359 and Kunji, Edmund R. S.
(2024)
Structural mechanisms of mitochondrial uncoupling protein 1 regulation in thermogenesis.
Trends in Biochemical Sciences, 49 (6).
pp. 506-519.
ISSN 0968-0004
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Abstract
In mitochondria, the oxidation of nutrients is coupled to ATP synthesis by the generation of a protonmotive force across the mitochondrial inner membrane. In mammalian brown adipose tissue (BAT), uncoupling protein 1 (UCP1, SLC25A7), a member of the SLC25 mitochondrial carrier family, dissipates the protonmotive force by facilitating the return of protons to the mitochondrial matrix. This process short-circuits the mitochondrion, generating heat for non-shivering thermogenesis. Recent cryo-electron microscopy (cryo-EM) structures of human UCP1 have provided new molecular insights into the inhibition and activation of thermogenesis. Here, we discuss these structures, describing how purine nucleotides lock UCP1 in a proton-impermeable conformation and rationalizing potential conformational changes of this carrier in response to fatty acid activators that enable proton leak for thermogenesis.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: UKRI Medical Research Council (MC_UU_00028/2) and Biotechnology and Biological Sciences Research Council (BB/S00940X/1). |
| Uncontrolled Keywords: | bioenergetics,brown adipose tissue,non-shivering thermogenesis,slc25 mitochondrial carrier family,thermogenin,ucp1,biochemistry,molecular biology ,/dk/atira/pure/subjectarea/asjc/1300/1303 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 16 Apr 2024 12:30 |
| Last Modified: | 03 Jun 2024 16:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/94915 |
| DOI: | 10.1016/j.tibs.2024.03.005 |
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