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Gregory, Sarah, Griffiths, Alex, Jennings, Amy, Malcomson, Fiona C., Matu, Jamie, Minihane, Anne-Marie 
ORCID: https://orcid.org/0000-0001-9042-4226, Muniz-Terrera, Graciela, Ritchie, Craig W., Parra-Soto, Solange, Stevenson, Emma, Townsend, Rebecca, Ward, Nicola Ann and Shannon, Oliver
(2024)
Adherence to the Eatwell Guide and cardiometabolic, cognitive and neuroimaging parameters: An analysis from the PREVENT dementia study.
Nutrition & Metabolism, 21.
ISSN 1743-7075
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Abstract
Background: The Eatwell guide reflects the UK government’s recommendations for a healthy and balanced diet. Previous research has identified associations between healthy eating patterns and both cardiovascular and brain health, although there is little evidence specifically focusing on the Eatwell Guide. To date no research has investigated associations between the Eatwell Guide and risk for future dementia. Methods: Data from the PREVENT dementia cohort study baseline visit was used in this analysis. Binary and graded Eatwell Guide scores (BEWG, GEWG) were created from a self-reported Food Frequency Questionnaire. The CAIDE score was included as the primary outcome measure to represent risk for future Alzheimer’s disease. Secondary outcome measures included cardiometabolic health measures and brain health measures. Generalised additive models were run in R. Results: A total of 517 participants were included in the analysis, with a mean BEWG score of 4.39 (±1.66) (out of a possible 12 points) and GEWG score of 39.88 (±6.19) (out of a possible 60 points). There was no significant association between either Eatwell Guide score and the CAIDE score (BEWG β: 0.07, 95% confidence interval (CI): -0.07, 0.22; GEWG β: 0.02, 95% CI: -0.02, 0.06) or any measures of brain health. There was a significant association between higher GEWG score and lower systolic and diastolic blood pressure and body mass index (BMI) (systolic β: -0.24, 95% CI: -0.45, -0.03; diastolic β: -0.16, 95% CI: -0.29, -0.03; BMI β: -0.09, 95% CI: -0.16, -0.01). Conclusions: Although not directly associated with the CAIDE score, the Eatwell Guide dietary pattern may be beneficial for dementia prevention efforts through the modification of hypertension and obesity, which are both known risk factors for dementia. Future work could replicate these findings in other UK-based cohorts as well as further development of Eatwell Guide scoring methodologies.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding information: PREVENT is funded by the Alzheimer’s Society (grant numbers 178, 264 and 329), Alzheimer’s Association (grant number TriBEKa-17–519007) and philanthropic donations. The analytical work was funded by the MRC (MRC UK Nutrition Research Partnership (NRP) Collaboration Award NuBrain (MR/T001852/1). Prof. Muniz-Terrera acknowledges the support of the Osteopathic Heritage Foundation through funding for the Osteopathic Heritage Foundation Ralph S. Licklider, D.O., Research Endowment in the Heritage College of Osteopathic Medicine. The funders had no involvement in the protocol design, data collection, analysis or manuscript preparation. |
| Uncontrolled Keywords: | diet,eatwell guide,cohort study,cardiometabolic health,nutrition and dietetics,endocrinology, diabetes and metabolism,medicine (miscellaneous),sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2900/2916 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 10 Apr 2024 12:30 |
| Last Modified: | 23 Apr 2024 09:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/94886 |
| DOI: | 10.1186/s12986-024-00794-z |
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