SnoRNAs in cardiovascular development, function, and disease

Chabronova, Alzbeta, Holmes, Terri L., Hoang, Duc M., Denning, Chris, James, Victoria, Smith, James G. W. ORCID: https://orcid.org/0000-0003-0427-8678 and Peffers, Mandy J. (2024) SnoRNAs in cardiovascular development, function, and disease. Trends in Molecular Medicine. ISSN 1471-4914

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Abstract

Small nucleolar RNAs (snoRNAs) are emerging as important regulators of cardiovascular (patho)biology. Several roles of snoRNAs have recently been identified in heart development and congenital heart diseases, as well as their dynamic regulation in hypertrophic and dilated cardiomyopathies, coronary heart disease (CHD), myocardial infarction (MI), cardiac fibrosis, and heart failure. Furthermore, reports of changes in vesicular snoRNA expression and altered levels of circulating snoRNAs in response to cardiac stress suggest that snoRNAs also function in cardiac signaling and intercellular communication. In this review, we summarize and discuss key findings and outline the clinical potential of snoRNAs considering current challenges and gaps in the field of cardiovascular diseases (CVDs).

Item Type:	Article
Uncontrolled Keywords:	biomarker,cardiac fibrosis,cardiomyopathy,exercise,extracellular vesicles,snorna,molecular medicine,molecular biology ,/dk/atira/pure/subjectarea/asjc/1300/1313
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	26 Mar 2024 10:30
Last Modified:	03 Apr 2024 09:31
URI:	https://ueaeprints.uea.ac.uk/id/eprint/94757
DOI:	10.1016/j.molmed.2024.03.004

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