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Chabronova, Alzbeta, Holmes, Terri L., Hoang, Duc M., Denning, Chris, James, Victoria, Smith, James G. W. 
ORCID: https://orcid.org/0000-0003-0427-8678 and Peffers, Mandy J.
(2024)
SnoRNAs in cardiovascular development, function, and disease.
Trends in Molecular Medicine, 30 (6).
pp. 562-578.
ISSN 1471-4914
Abstract
Small nucleolar RNAs (snoRNAs) are emerging as important regulators of cardiovascular (patho)biology. Several roles of snoRNAs have recently been identified in heart development and congenital heart diseases, as well as their dynamic regulation in hypertrophic and dilated cardiomyopathies, coronary heart disease (CHD), myocardial infarction (MI), cardiac fibrosis, and heart failure. Furthermore, reports of changes in vesicular snoRNA expression and altered levels of circulating snoRNAs in response to cardiac stress suggest that snoRNAs also function in cardiac signaling and intercellular communication. In this review, we summarize and discuss key findings and outline the clinical potential of snoRNAs considering current challenges and gaps in the field of cardiovascular diseases (CVDs).
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: Funding was received from the British Heart Foundation (SP/F/22/150044, CRMR/21/290009, and PG/21/10545) and Animal Free Research UK (AFR19-20293). The authors declare no competing interests. |
| Uncontrolled Keywords: | biomarker,cardiac fibrosis,cardiomyopathy,exercise,extracellular vesicles,snorna,molecular medicine,molecular biology ,/dk/atira/pure/subjectarea/asjc/1300/1313 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 26 Mar 2024 10:30 |
| Last Modified: | 12 Jun 2024 08:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/94757 |
| DOI: | 10.1016/j.molmed.2024.03.004 |
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