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Gonnah, Ahmed R., Abdelwahab, Mohamed, Taylor, Rebecca, Labib, Aser, Masoud, Omar, Debski, Maciej 
ORCID: https://orcid.org/0000-0002-3669-3916, Abdelaziz, Hesham Kamal and Roberts, David Hesketh
(2023)
Health-related quality of life following TAVI or cardiac surgery in patients at intermediate and low risk: a systematic review and meta-analysis.
Clinical Medicine, 23 (6).
pp. 594-605.
ISSN 1470-2118
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Abstract
Recent randomised trials have shown that clinical outcomes with transcatheter aortic valve implantation (TAVI) are non-inferior to surgical aortic valve replacement (SAVR) in patients with symptomatic aortic stenosis at intermediate to low risk. Health-related quality of life (HrQoL) outcomes in these patient groups remain uncertain. A systematic search of the literature was conducted that included nine trials and 11,295 patients. Kansas City Cardiomyopathy Questionnaire (KCCQ), a heart-failure-specific measure and EuroQol-5D (EQ-5D) (a generic health status tool) changes were the primary outcomes. New York Heart Association (NYHA) classification was the secondary outcome. Improvement in KCCQ scores was greater with TAVI (mean difference (MD)=13.56, 95% confidence interval (CI) 11.67–15.46, p<0.001) at 1 month, as was the improvement in EQ-5D (MD=0.07, 95% CI 0.05–0.08, p<0.001). There was no difference in KCCQ (MD=1.05, 95% CI −0.11 to 2.21, p=0.08) or EQ-5D (MD=–0.01, 95% CI −0.03 to 0.01), p=0.37) at 12 months. NYHA functional class 3/4 was lower in patients undergoing TAVI at 1 month (MD=0.51, 95% CI 0.34–0.78, p=0.002), but there was no difference at 12 months (MD=1.10; 95% CI 0.87–1.38, p=0.43). Overall, TAVI offers early benefit in HRQoL outcomes compared with SAVR, but they are equivalent at 12 months.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | eq-5d,kccq,nyha,savr,tavi,aortic stenosis,medicine(all) ,/dk/atira/pure/subjectarea/asjc/2700 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 25 Mar 2024 15:30 |
| Last Modified: | 10 Dec 2024 01:43 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/94752 |
| DOI: | 10.7861/clinmed.2023-0258 |
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