Strategies for converting turn-motif and cyclic peptides to small molecules for targeting protein–protein interactions

Hayward, Deanne and Beekman, Andrew M. ORCID: https://orcid.org/0000-0002-3056-6406 (2024) Strategies for converting turn-motif and cyclic peptides to small molecules for targeting protein–protein interactions. RSC Chemical Biology, 5 (3). pp. 198-208. ISSN 2633-0679

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Abstract

The development of small molecules that interact with protein–protein interactions is an ongoing challenge. Peptides offer a starting point in the drug discovery process for targeting protein-interactions due to their larger, more flexible structure and the structurally diverse properties that allow for a greater interaction with the protein. The techniques for rapidly identifying potent cyclic peptides and turn-motif peptides are highly effective, but this potential has not yet transferred to approved drug candidates. By applying the properties of the peptide–protein interaction the development of small molecules for drug discovery has the potential to be more efficient. In this review, we discuss the methods that allow for the unique binding properties of peptides to proteins, and the methods deployed to transfer these qualities to potent small molecules.

Item Type: Article
Additional Information: Acknowledgements: DH and AMB acknowledges Big C Cancer Charity for a project grant (19-13R). AMB acknowledges funding from the Royal Society (RGS\R1\201008).
Faculty \ School: Faculty of Science > School of Pharmacy (former - to 2024)
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Depositing User: LivePure Connector
Date Deposited: 04 Mar 2024 18:38
Last Modified: 16 Dec 2024 01:41
URI: https://ueaeprints.uea.ac.uk/id/eprint/94554
DOI: 10.1039/D3CB00222E

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