The plant immune receptor SNC1 monitors helper NLRs targeted by a bacterial effector

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Wang, Ming Yu, Chen, Jun Bin, Wu, Rui, Guo, Hai Long, Chen, Yan, Li, Zhen Ju, Wei, Lu Yang, Liu, Chuang, He, Sheng Feng, Du, Mei Da, Guo, Ya long, Peng, You Liang, Jones, Jonathan D. G., Weigel, Detlef, Huang, Jian-Hua and Zhu, Wang Sheng (2023) The plant immune receptor SNC1 monitors helper NLRs targeted by a bacterial effector. Cell Host and Microbe, 31 (11). 1792-1803.e7. ISSN 1931-3128

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Abstract

Plants deploy intracellular receptors to counteract pathogen effectors that suppress cell-surface-receptor-mediated immunity. To what extent pathogens manipulate intracellular receptor-mediated immunity, and how plants tackle such manipulation, remains unknown. Arabidopsis thaliana encodes three similar ADR1 class helper nucleotide-binding domain leucine-rich repeat receptors (ADR1, ADR1-L1, and ADR1-L2), which are crucial in plant immunity initiated by intracellular receptors. Here, we report that Pseudomonas syringae effector AvrPtoB suppresses ADR1-L1- and ADR1-L2-mediated cell death. ADR1, however, evades such suppression by diversifying into two ubiquitination sites targeted by AvrPtoB. The intracellular sensor SNC1 interacts with and guards the CCR domains of ADR1-L1/L2. Removal of ADR1-L1/L2 or delivery of AvrPtoB activates SNC1, which then signals through ADR1 to trigger immunity. Our work elucidates the long-sought-after function of SNC1 in defense, and also how plants can use dual strategies, sequence diversification, and a multi-layered guard-guardee system, to counteract pathogen's attack on core immunity functions.

Item Type: Article
Additional Information: Funding Information: R.W. was supported by the EU Horizon 2020 research and innovation program under the Marie Skłodowska-Curie scheme (H2020-MSCA-IF-2014-655295). J.D.G.J. was supported by the Gatsby Foundation (UK). D.W. was supported by ERC-SyG PATHOCOM 951444 and the Max Planck Society. J.-H.H. was supported by the EUs Horizon 2020 research and innovation program under the Marie Skłodowska-Curie scheme (no 897584). W.-S.Z. was supported by the National Key Research and Development Program, Ministry of Science and Technology of China (no 2022YFD1201802), the Ministry of Education of China (the 111 Project B13006), and the 2115 Talent Development Program of China Agricultural University (no 2020RC013). Data and code availability: This study analyses existing, publicly available data and does not generate new datasets and sequences. Information on the publicly available data is listed in the key resources table. All data are provided in the main figures and supplemental figures. Original data have been deposited to Mendeley Data (https://doi.org/10.17632/ph4y2sjbhc.1): https://data.mendeley.com/datasets/ph4y2sjbhc/1.
Uncontrolled Keywords: adr1s,e3 ubiquitin ligase,effector-triggered immunity,helper nlrs,plant and microbe interactions,plant immunity,pseudomonas effector,snc1,parasitology,microbiology,virology ,/dk/atira/pure/subjectarea/asjc/2400/2405
Faculty \ School: Faculty of Science > School of Biological Sciences
Faculty of Science > The Sainsbury Laboratory
UEA Research Groups: Faculty of Science > Research Groups > Plant Sciences
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Depositing User: LivePure Connector
Date Deposited: 04 Mar 2024 18:22
Last Modified: 04 Mar 2024 18:22
URI: https://ueaeprints.uea.ac.uk/id/eprint/94431
DOI: 10.1016/j.chom.2023.10.006

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