The utility of arterial spin labeling MRI in medial temporal lobe as a vascular biomarker in Alzheimer’s disease spectrum: A systematic review and meta-analysis

Kapasouri, Efthymia Maria, Ioannidis, Diomidis C., Cameron, Donnie ORCID: https://orcid.org/0000-0001-9841-6909, Vassiliou, Vassilios S. ORCID: https://orcid.org/0000-0002-4005-7752 and Hornberger, Michael ORCID: https://orcid.org/0000-0002-2214-3788 (2022) The utility of arterial spin labeling MRI in medial temporal lobe as a vascular biomarker in Alzheimer’s disease spectrum: A systematic review and meta-analysis. Diagnostics, 12 (12). ISSN 2075-4418

[thumbnail of diagnostics-12-02967-v2]
Preview
PDF (diagnostics-12-02967-v2) - Published Version
Available under License Creative Commons Attribution.

Download (1MB) | Preview

Abstract

We sought to systematically review and meta-analy the role of cerebral blood flow (CBF) in the medial temporal lobe (MTL) using arterial spin labeling magnetic resonance imaging (ASL-MRI) and compare this in patients with Alzheimer’s disease (AD), individuals with mild cognitive impairment (MCI), and cognitively normal adults (CN). The prevalence of AD is increasing and leading to high healthcare costs. A potential biomarker that can identify people at risk of developing AD, whilst cognition is normal or only mildly affected, will enable risk-stratification and potential therapeutic interventions in the future. All studies investigated the role of CBF in the MTL and compared this among AD, MCI, and CN participants. A total of 26 studies were included in the systematic review and 11 in the meta-analysis. Three separate meta-analyses were conducted. Four studies compared CBF in the hippocampus of AD compared with the CN group and showed that AD participants had 2.8 mL/min/100 g lower perfusion compared with the CN group. Eight studies compared perfusion in the hippocampus of MCI vs. CN group, which showed no difference. Three studies compared perfusion in the MTL of MCI vs. CN participants and showed no statistically significant differences. CBF measured via ASL-MRI showed impairment in AD compared with the CN group in subregions of the MTL. CBF difference was significant in hippocampus between the AD and CN groups. However, MCI and CN group showed no significant difference in subregions of MTL.

Item Type: Article
Additional Information: Funding Information: This review received no external funding. Publisher Copyright: © 2022 by the authors.
Uncontrolled Keywords: arterial spin labeling,asl,cerebral blood flow,dementia,medial temporal lobe,mild cognitive decline,mri,clinical biochemistry ,/dk/atira/pure/subjectarea/asjc/1300/1308
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Science > Research Groups > Norwich Epidemiology Centre
Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre
Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging
Faculty of Medicine and Health Sciences > Research Groups > Mental Health
Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 17 Jan 2024 01:37
Last Modified: 18 Jan 2024 01:36
URI: https://ueaeprints.uea.ac.uk/id/eprint/94190
DOI: 10.3390/diagnostics12122967

Actions (login required)

View Item View Item