Tools
Tools
Merinopoulos, Ioannis, Bhalraam, U., Holmes, Terri, Tsampasian, Vasiliki, Corballis, Natasha, Gunawardena, Tharusha, Sawh, Chris, Maart, Clint, Wistow, Trevor, Ryding, Alisdair, Eccleshall, Simon C., Smith, James 
ORCID: https://orcid.org/0000-0003-0427-8678 and Vassiliou, Vassilios S. ORCID: https://orcid.org/0000-0002-4005-7752
(2023)
Circulating intermediate monocytes CD14++CD16+ are increased after elective percutaneous coronary intervention.
PLoS One, 18 (12).
ISSN 1932-6203
Preview |
PDF (journal.pone.0294746)
- Published Version
Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
Aim Inflammation plays a central role in the pathogenesis of atherosclerosis and in the sequelae of percutaneous coronary intervention (PCI). Previous work demonstrated that intermediate monocytes (CD14++CD16+) are associated with adverse cardiovascular events, yet monocyte subset response following elective PCI has not been described. This article explores the changes in monocyte subset and humoral response after elective PCI. Methods This prospective study included 30 patients without inflammatory diseases being referred for elective PCI. We included patients treated with drug coated balloons or 2nd generation drug eluting stents. Patients underwent blood tests at baseline (prior to PCI), four hours, two weeks and two months later. Analyses were performed in terms of monocyte subsets (classical CD14++CD16-, intermediate CD14++CD16+ and non-classical CD14+CD16++), gene expression of CD14+ leucocytes and humoral biomarkers. Results Intermediate monocytes decreased significantly four hours after PCI, were recovered at two weeks, and increased significantly at two months post elective, uncomplicated PCI. They remain significantly elevated in the DES group but not in the DCB group. Gene expression analysis of CD14+ leucocytes showed IL18 had decreased expression at two weeks, CXCR4 and IL1β decreased at two months, while pentraxin 3 increased at two weeks and two months. In terms of humoral biomarkers, hsTnI remains elevated up to two weeks post PCI while IL6 and TNFα remain elevated till two months post PCI. Conclusion Intermediate monocytes increase significantly two months following elective, uncomplicated PCI. They remain significantly elevated in the DES group but not in the DCB group suggesting that the PCI strategy could be one of the ways to modulate the inflammatory response post PCI.
| Item Type: | Article |
|---|---|
| Additional Information: | Data Availability: all data available through Figshare repository DOI: 10.6084/m9.figshare.24201339 located at: https://figshare.com/account/login. Funding information: This is an investigator-initiated study partially supported by the National Institute for Health Research Capability Fund from Norfolk and Norwich University Hospital, Norfolk Heart Trust and B Braun Ltd. Drs Bhalraam, Corballis and Tsampasian received funding from the NIHR as Academic Clinical Fellow. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 17 Jan 2024 01:36 |
| Last Modified: | 18 Jan 2024 01:35 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/94185 |
| DOI: | 10.1371/journal.pone.0294746 |
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |