Pharmacology and pharmacokinetics of vitamin D

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Schoenmakers, Inez and Jones, Kerry S. (2024) Pharmacology and pharmacokinetics of vitamin D. In: Feldman and Pike's Vitamin D. Elsevier, pp. 633-668. ISBN 9780323913867

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Abstract

This chapter describes the metabolic parameters of vitamin D and its metabolites according to the framework of pharmacokinetics. The pharmacokinetics of vitamin D is considerably more complex than a standard pharmacological agent, because of the required stepwise hydroxylation into the active form, 1,25(OH)2D, its endogenous, cutaneous synthesis, and presence of vitamin D and its metabolites in the circulation and tissues. Also, its binding to the vitamin D–binding protein (DBP) influences the properties of the vitamin D metabolites. These aspects are discussed throughout this chapter. The absorption, distribution, dose-response, metabolism, excretion, and toxicity of vitamin D and its metabolites are reviewed. In addition, we present the current knowledge of factors influencing 25-hydroxyvitamin D half-life, the influence of DBP on vitamin D metabolism, and the differences in pharmacokinetics between bound and free 25-hydroxyvitamin D.

Item Type:	Book Section
Uncontrolled Keywords:	catabolism and excretion,dose-response,free 25(oh)d,metabolism,plasma and tissue half-life,tissue distribution,toxicity,vitamin d absorption,vitamin d binding protein,arts and humanities(all) ,/dk/atira/pure/subjectarea/asjc/1200
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	08 Nov 2023 03:43
Last Modified:	20 Dec 2023 03:07
URI:	https://ueaeprints.uea.ac.uk/id/eprint/93600
DOI:	10.1016/B978-0-323-91386-7.00007-6

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