Microbiome diversity is a modifiable virulence factor for Cryptosporidiosis

Hurle, Georgina R. ORCID: https://orcid.org/0000-0003-0033-2585, Brainard, Julii and Tyler, Kevin M. ORCID: https://orcid.org/0000-0002-0647-8158 (2023) Microbiome diversity is a modifiable virulence factor for Cryptosporidiosis. Virulence, 14 (1). ISSN 2150-5594

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Abstract

Cryptosporidium spp. infection causes significant disease in immunosuppressed individuals and children under the age of 5 years. The severity of the pathological presentation of cryptosporidiosis is a function of the host and parasite genotypes, host immune status, and the enteric environment or microbiome of the host. Cryptosporidiosis often presents with abdominal pain and severe diarrhoea and is associated with intestinal dysbiosis and inflammation. Our systematic analysis of the available literature revealed that bacterial diversity is reduced during infection in larger animal models, lending support to recent studies which indicate that the use of probiotics or the presence of a naturally diverse gut microbiome can prevent or minimise pathology caused by gastrointestinal pathogens. In summary, we present evidence that the presence of a diverse gut microbiome, natural or induced, reduces both symptomatic pathology and oocyst output.

Item Type:	Article
Additional Information:	Funding information: This work was supported by the Interreg 2 Seas program 2014–2020, co-funded by the European Regional Development Fund under subsidy contract no. 2S05–043 H4DC to K.M.T.
Uncontrolled Keywords:	cryptosporidium parvum,;cryptosporidium hominis,gut,microbiome,microbiota,meta-analysis,systematic review,dysbiosis,metagenome,veterinary(all),genetics,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/3400
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	17 Oct 2023 00:46
Last Modified:	22 Nov 2023 04:37
URI:	https://ueaeprints.uea.ac.uk/id/eprint/93325
DOI:	10.1080/21505594.2023.2273004

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