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Stewart, Sarah-Jane F., Pandolfo, Alyssa M., Moon, Zoe, Jani, Yogini, Brett, Stephen J., Brealey, David, Singh, Suveer, Enne, Virve I., Livermore, David M. 
ORCID: https://orcid.org/0000-0002-9856-3703, Gant, Vanya and Horne, Robert
and
INHALE Study Group
(2024)
UK clinicians’ attitudes towards the application of molecular diagnostics to guide antibiotic use in ICU patients with pneumonias: A quantitative study.
Journal of Antimicrobial Chemotherapy, 79 (1).
123–127.
ISSN 0305-7453
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Abstract
Background: Molecular diagnostic tests may improve antibiotic prescribing by enabling earlier tailoring of antimicrobial therapy. However, clinicians’ trust and acceptance of these tests will determine their application in practice. Objectives: To examine ICU prescribers’ views on the application of molecular diagnostics in patients with suspected hospital-acquired and ventilator-associated pneumonia (HAP/VAP). Methods: Sixty-three ICU clinicians from five UK hospitals completed a cross-sectional questionnaire between May 2020 and July 2020 assessing attitudes towards using molecular diagnostics to inform initial agent choice and to help stop broad-spectrum antibiotics early. Results: Attitudes towards using molecular diagnostics to inform initial treatment choices and to stop broad-spectrum antibiotics early were nuanced. Most (83%) were positive about molecular diagnostics, agreeing that using results to inform broad-spectrum antibiotic prescribing is good practice. However, many (58%) believed sick patients are often too unstable to risk stopping broad-spectrum antibiotics based on a negative result. Conclusions: Positive attitudes towards the application of molecular diagnostics to improve antibiotic stewardship were juxtapositioned against the perceived need to initiate and maintain broad-spectrum antibiotics to protect unstable patients.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding information: This work was supported by the National Institute for Health Research (NIHR) under its Programme Grants for Applied Research Programme (RP-PG-0514-493 20018). The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. The funder had no role in the study design, in the collection, analysis and interpretation of data, in the writing of the report or in the decision to submit the article for publication. |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 17 Oct 2023 00:46 |
| Last Modified: | 20 Jan 2024 01:34 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/93324 |
| DOI: | 10.1093/jac/dkad355 |
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