Antiparasitic activity of ivermectin: Four decades of research into a “wonder drug”

Sulik, Michal, Antoszczak, Michał, Huczyński, Adam and Steverding, Dietmar (2023) Antiparasitic activity of ivermectin: Four decades of research into a “wonder drug”. European Journal of Medicinal Chemistry, 261. ISSN 0223-5234

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Abstract

Parasitic diseases still pose a serious threat to human and animal health, particularly for millions of people and their livelihoods in low-income countries. Therefore, research into the development of effective antiparasitic drugs remains a priority. Ivermectin, a sixteen-membered macrocyclic lactone, exhibits a broad spectrum of antiparasitic activities, which, combined with its low toxicity, has allowed the drug to be widely used in the treatment of parasitic diseases affecting humans and animals. In addition to its licensed use against river blindness and strongyloidiasis in humans, and against roundworm and arthropod infestations in animals, ivermectin is also used “off-label” to treat many other worm-related parasitic diseases, particularly in domestic animals. In addition, several experimental studies indicate that ivermectin displays also potent activity against viruses, bacteria, protozoans, trematodes, and insects. This review article summarizes the last 40 years of research on the antiparasitic effects of ivermectin, and the use of the drug in the treatment of parasitic diseases in humans and animals.

Item Type:	Article
Additional Information:	Funding Information: M.S. wishes to acknowledge the Polish Ministry of Education and Science (MEiN) for financial support by a Diamond Grant ( 0159/DIA/2020/49 ). M.A. wishes to acknowledge the MEiN for the scholarship for outstanding young scientists in the years 2020–2023 (STYP/15/1665/E-336/2020).
Uncontrolled Keywords:	antiparasitic activity,experimental use,ivermectin,licensed use,“off-label” use,drug discovery,pharmacology,organic chemistry,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/3000/3002
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	07 Oct 2023 01:23
Last Modified:	14 Oct 2023 00:53
URI:	https://ueaeprints.uea.ac.uk/id/eprint/93143
DOI:	10.1016/j.ejmech.2023.115838

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