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Artuso, Irene, Poddar, Harsh, Evans, Benjamin A. 
ORCID: https://orcid.org/0000-0001-6849-9758 and Visca, Paolo
(2023)
Genomics of Acinetobacter baumannii iron uptake.
Microbial Genomics, 9 (8).
ISSN 2057-5858
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Abstract
Iron is essential for growth in most bacteria due to its redox activity and its role in essential metabolic reactions; it is a cofactor for many bacterial enzymes. The bacterium Acinetobacter baumannii is a multidrug-resistant nosocomial pathogen. A. baumannii responds to low iron availability imposed by the host through the exploitation of multiple iron-acquisition strategies, which are likely to deliver iron to the cell under a variety of environmental conditions, including human and animal infection. To date, six different gene clusters for active iron uptake have been described in A. baumannii , encoding protein systems involved in (i) ferrous iron uptake (feo); (ii) haem uptake (hemT and hemO); and (iii) synthesis and transport of the baumannoferrin(s) (bfn), acinetobactin (bas/bau) and fimsbactin(s) (fbs) siderophores. Here we describe the structure, distribution and phylogeny of iron-uptake gene clusters among >1000 genotypically diverse A. baumannii isolates, showing that feo, hemT, bfn and bas/bau clusters are very prevalent across the dataset, whereas the additional haem-uptake system hemO is only present in a portion of the dataset and the fbs gene cluster is very rare. Since the expression of multiple iron-uptake clusters can be linked to virulence, the presence of the additional haem-uptake system hemO may have contributed to the success of some A. baumannii clones.
| Item Type: | Article |
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| Additional Information: | Funding Information: This work was funded by grants from Rome Technopole Foundation (Spoke 1, CUP F83B22000040006), the National Biodiversity Future Centre (Spoke 3, CUP F83C22000730006) Grant no. A0375-2020-36558 GAVAP from Regione Lazio and MUR-PRIN 2017, grant prot. 20177J5Y3P to P.V. I.A. thanks the Federation of European Microbiological Societies (FEMS) for supporting her research at Norwich Medical School with a Research and Training grant. |
| Uncontrolled Keywords: | acinetobacter baumannii,haem,iron uptake,phylogeny,sequence type,siderophore,epidemiology,microbiology,molecular biology,genetics ,/dk/atira/pure/subjectarea/asjc/2700/2713 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Pathogen Biology Group |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 18 Aug 2023 09:32 |
| Last Modified: | 15 Dec 2024 01:27 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/92882 |
| DOI: | 10.1099/mgen.0.001080 |
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