Cycle numbers of cell surface recycling receptors

Steverding, Dietmar (2023) Cycle numbers of cell surface recycling receptors. Receptors, 2 (2). pp. 160-165. ISSN 2813-2564

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Abstract

The cycle number (nc) of a recycling receptor is defined as the average number of round trips (cell surface – endosome - cell surface) the receptor can make before being degraded. This characteristic parameter of recycling receptors can be easily determined from the receptor’s half-life (t½, the time in which 50% of the receptor is degraded) and cycling time (Tc, the time a receptor needs to complete a round trip). Relationship analyses revealed that nc increases linearly with increasing t½ and decreases exponentially with increasing Tc. For commonly observed t½ and Tc values, it was calculated that recycling receptors have nc values of <300. In addition, it was found that recycling receptors in cancer cells have generally smaller nc values (<100) whereas recycling receptors in normal cells have larger nc values (>100). Based on this latter finding, the cycle number nc may be a useful criterion to distinguish between cancer and normal cells.

Item Type:	Article
Additional Information:	Data Availability Statement: No new data were created or analyzed in this study.
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User:	LivePure Connector
Date Deposited:	02 Jun 2023 08:31
Last Modified:	12 Jun 2023 08:34
URI:	https://ueaeprints.uea.ac.uk/id/eprint/92252
DOI:	10.3390/receptors2020010

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