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Lim, Chong Seng Edwin, Tremelling, Mark, Hamilton, Louise, Kim, Matthew, MacGregor, Alexander 
ORCID: https://orcid.org/0000-0003-2163-2325, Turmezei, Tom and Gaffney, Karl ORCID: https://orcid.org/0000-0002-7863-9176
(2023)
Prevalence of undiagnosed axial spondyloarthritis in inflammatory bowel disease patients with chronic back pain: secondary care cross-sectional study.
Rheumatology, 62 (4).
pp. 1511-1518.
ISSN 1462-0324
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Abstract
Objective: To elucidate the prevalence of undiagnosed rheumatology-verified diagnosis of axial spondyloarthritis (RVD-axSpA) in patients attending routine secondary care IBD clinics with chronic back pain. Methods: Screening questionnaires were sent to consecutive patients attending IBD clinics in a university teaching hospital. Patients fulling the eligibility criteria (gastroenterologist-verified diagnosis, 18–80 years old, biologic therapy naive, no previous diagnosis of axSpA); and a moderate diagnostic probability of axSpA [self-reported chronic back pain (CBP) >3 months, onset <45 years] were invited for rheumatology assessment. This included medical review, physical examination, patient reported outcome measures, human leucocyte antigen B27, C-reactive protein, pelvic radiograph and axSpA protocol magnetic resonance imaging. A diagnosis of RVD-axSpA was made by a panel of rheumatologists. Results: Of the 470 patients approached, 91 had self-reported CBP >3 months, onset <45 years, of whom 82 were eligible for clinical assessment. The prevalence of undiagnosed RVD-axSpA in patients attending IBD clinics in a secondary care setting, with self-reported CBP, onset <45 years is estimated at 5% (95% CI 1.3, 12.0) with a mean symptom duration of 12 (S.D. 12.4) years. Conclusion: There is a significant hidden disease burden of axSpA among IBD patients. Appropriate identification and referral from gastroenterology is needed to potentially shorten the delay to diagnosis and allow access to appropriate therapy.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: 2020 EULAR European E-Congress of Rheumatology [31] and the ACR Convergence 2020 [32]. The National Axial Spondyloarthritis Society (NASS, CT3557/17/E11) and The Norfolk and Norwich Hospital Charity (37996/17/F110). Publisher Copyright: © The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. |
| Uncontrolled Keywords: | axial spondyloarthritis,back pain,epidemiology,inflammatory bowel disease,magnetic resonance imaging,rheumatology,pharmacology (medical) ,/dk/atira/pure/subjectarea/asjc/2700/2745 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 22 May 2023 14:30 |
| Last Modified: | 07 Oct 2023 01:19 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/92122 |
| DOI: | 10.1093/rheumatology/keac473 |
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